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1

[IEEE 2019 Symposium on VLSI Technology - Kyoto, Japan (2019.6.9-2019.6.14)] 2019 Symposium on VLSI Technology - First demonstration of 40-nm channel length top-gate WS 2 pFET using channel area-selective CVD growth directly on SiO x /Si substrate

Cheng, Chao-Ching, Chung, Yun-Yan, Li, Uing-Yang, Lin, Chao-Ting, Li, Chi-Feng, Chen, Jyun-Hong, Lai, Tung-Yen, Li, Kai-Shin, Shieh, Jia-Min, Su, Sheng-Kai, Chiang, Hung-Li, Chen, Tzu-Chiang, Li, Lain

Year:

2019

Language:

english

File:

PDF, 1.37 MB

english, 2019

2

Inhibition of nuclear factor-κB activation un-masks the ability of TNF-α to induce human eosinophil apoptosis

Satoko Fujihara, Carol Ward, Ian Dransfield, Ronald T. Hay, Iain J. Uings, Brian Hayes, Stuart N. Farrow, Christopher Haslett, Adriano G. Rossi

Journal:

European Journal of Immunology

Year:

2002

Language:

english

File:

PDF, 273 KB

english, 2002

3

Cyclic peptide interleukin 5 antagonists mimic CD turn recognition epitope for receptor α

Piotr Ruchala, Gyorgyi Varadi, Tetsuya Ishino, Jeffery Scibek, Madhushree Bhattacharya, Cecilia Urbina, Donald Van Ryk, Iain Uings, Irwin Chaiken

Journal:

Year:

2004

Language:

english

File:

PDF, 307 KB

english, 2004

4

The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist

Kevin P. Madauss, Randy K. Bledsoe, Iain Mclay, Eugene L. Stewart, Iain J. Uings, Gordon Weingarten, Shawn P. Williams

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 427 KB

english, 2008

5

Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists

Keith Biggadike, Matilde Caivano, Margaret Clackers, Diane M. Coe, George W. Hardy, Davina Humphreys, Haydn T. Jones, David House, Annette Miles-Williams, Philip A. Skone, Iain Uings, Vicki Weller, Ia

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 753 KB

english, 2009

6

The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist

Joseph Rimland, Angela Dunne, Suchete S. Hunjan, Rosemary Sasse, Iain Uings, Dino Montanari, Matilde Caivano, Poonam Shah, David Standing, David Gray, David Brown, William Cairns, Ryan Trump, Paul W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 392 KB

english, 2010

7

Effects of dexamethasone on TNF-alpha-induced release of cytokines from purified human blood eosinophils

Iain Uings, Ilaria Puxeddu, Vladislav Temkin, Susan J Smith, Dilniya Fattah, Keith P Ray, Francesca Levi-Schaffer

Journal:

Clinical and Molecular Allergy

Year:

2005

Language:

english

File:

PDF, 746 KB

english, 2005

8

Nocturnal enuresis and the use of desmopressin: is it helpful?

R Bath, R Morton, A Uing, C Williams

Journal:

Child: Care, Health and Development

Year:

1996

Language:

english

File:

PDF, 550 KB

english, 1996

9

Effects of the Indolocarbazole 3744W on the Tyrosine Kinase Activity of the Cytoplasmic Domain of the Platelet-Derived Growth Factor β-Receptor

Iain J. Uings, Graham D. Spacey, Robert W. Bonser

Journal:

Cellular Signalling

Year:

1999

Language:

english

File:

PDF, 304 KB

english, 1999

10

MODIFIED PEPTIDE ANTAGONISTS OF INTERLEUKIN 5 EXHIBIT EXTENDED IN VIVO PERSISTENCE BUT RESTRICTED SPECIES SPECIFICITY

Iain J. Uings, Palaniappan Balasubramanian, Patricia G. McLoughlin, Qun Yin, Laura Dash, Alan Beresford, Sarah Kearney, Ronald W. Barrett, Murray McKinnon, Bruce P. England

Journal:

Year:

2001

Language:

english

File:

PDF, 750 KB

english, 2001

11

A pharmacological approach to enhancing the therapeutic index of corticosteroids in airway inflammatory disease

Iain J Uings, Stuart N Farrow

Journal:

Current Opinion in Pharmacology

Year:

2005

Language:

english

File:

PDF, 109 KB

english, 2005

12

Functional analysis of the interleukin-5 receptor antagonist peptide, AF18748

Marcela Rosas, Iain J Uings, Cornelli van Aalst, Jan-Willem J Lammers, Leo Koenderman, Paul J Coffer

Journal:

Year:

2004

Language:

english

File:

PDF, 319 KB

english, 2004

13

Glucocorticoid-induced osteopenia in the mouse as assessed by histomorphometry, microcomputed tomography, and biochemical markers

F. McLaughlin, J. Mackintosh, B.P. Hayes, A. McLaren, I.J. Uings, P. Salmon, J. Humphreys, E. Meldrum, S.N. Farrow

Journal:

Year:

2002

Language:

english

File:

PDF, 134 KB

english, 2002

14

Indolocarbazoles: Potent and Selective Inhibitors of Platelet-Derived Growth Factor Receptor Autophosphorylation

Graham D Spacey, Iain J Uings, Martin Slater, Stuart Hirst, Robert W Bonser

Journal:

Biochemical Pharmacology

Year:

1998

Language:

english

File:

PDF, 580 KB

english, 1998

15

Progesterone Receptor Ligand Binding Pocket Flexibility: Crystal Structures of the Norethindrone and Mometasone Furoate Complexes

Madauss, Kevin P., Deng, Su-Jun, Austin, Robert J. H., Lambert, Millard H., McLay, Iain, Pritchard, John, Short, Steven A., Stewart, Eugene L., Uings, Ian J., Williams, Shawn P.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 1.69 MB

english, 2004

16

Lead Discovery for Human Kynurenine 3-Monooxygenase by High-Throughput RapidFire Mass Spectrometry

Lowe, D. M., Gee, M., Haslam, C., Leavens, B., Christodoulou, E., Hissey, P., Hardwicke, P., Argyrou, A., Webster, S. P., Mole, D. J., Wilson, K., Binnie, M., Yard, B. A., Dean, T., Liddle, J., Uings,

Journal:

Journal of Biomolecular Screening

Year:

2014

Language:

english

File:

PDF, 865 KB

english, 2014

17

Structure Guided Design of 5-Arylindazole Glucocorticoid Receptor Agonists and Antagonists

Yates, Christopher M., Brown, Peter J., Stewart, Eugene L., Patten, Christopher, Austin, Robert J. H., Holt, Jason A., Maglich, Jodi M., Angell, Davina C., Sasse, Rosemary Z., Taylor, Simon J., Uings,

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.15 MB

english, 2010

18

Development of IL-5 Receptor Antagonists

Uings, Iain, McKinnon, Murray

Journal:

Current Pharmaceutical Design

Year:

2002

Language:

english

File:

PDF, 112 KB

english, 2002

19

Discovery of GW870086: a potent anti-inflammatory steroid with a unique pharmacological profile

Uings, I J, Needham, D, Matthews, J, Haase, M, Austin, R, Angell, D, Leavens, K, Holt, J, Biggadike, K, Farrow, S N

Journal:

British Journal of Pharmacology

Year:

2013

Language:

english

File:

PDF, 2.06 MB

english, 2013

20

Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor

Biggadike, K., Bledsoe, R. K., Coe, D. M., Cooper, T. W. J., House, D., Iannone, M. A., Macdonald, S. J. F., Madauss, K. P., McLay, I. M., Shipley, T. J., Taylor, S. J., Tran, T. B., Uings, I. J., Wel

Journal:

Proceedings of the National Academy of Sciences

Year:

2009

Language:

english

File:

PDF, 1.01 MB

english, 2009

21

A potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor alpha chains

England, B. P., Balasubramanian, P., Uings, I., Bethell, S., Chen, M.-J., Schatz, P. J., Yin, Q., Chen, Y.-F., Whitehorn, E. A., Tsavaler, A., Martens, C. L., Barrett, R. W., McKinnon, M.

Journal:

Proceedings of the National Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 237 KB

english, 2000

22

Spatial Orientation of the and c Receptor Chain Binding Sites on Monomeric Human Interleukin-5 Constructs

Edgerton, M. D., Graber, P., Willard, D., Consler, T., McKinnon, M., Uings, I., Arod, C. Y., Borlat, F., Fish, R., Peitsch, M. C., Wells, T. N. C., Proudfoot, A. E. I.

Journal:

Journal of Biological Chemistry

Year:

1997

Language:

english

File:

PDF, 907 KB

english, 1997

23

Mometasone furoate is a less specific glucocorticoid than fluticasone propionate

Austin, R.J.H., Maschera, B., Walker, A., Fairbairn, L., Meldrum, E., Farrow, S.N., Uings, I.J.

Journal:

European Respiratory Journal

Year:

2002

Language:

english

File:

PDF, 115 KB

english, 2002

24

An Interleukin 5 Mutant Distinguishes between Two Functional Responses in Human Eosinophils

McKinnon, M., Page, K., Uings, I. J., Banks, M., Fattah, D., Proudfoot, A. E.I., Graber, P., Arod, C., Fish, R., Wells, T. N.C., Solari, R.

Journal:

Journal of Experimental Medicine

Year:

1997

Language:

english

File:

PDF, 197 KB

english, 1997

25

Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease

Salter, M., Biggadike, K., Matthews, J. L., West, M. R., Haase, M. V., Farrow, S. N., Uings, I. J., Gray, D. W.

Journal:

AJP Lung Cellular and Molecular Physiology

Year:

2007

Language:

english

File:

PDF, 214 KB

english, 2007

26

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

Mole, Damian J, Webster, Scott P, Uings, Iain, Zheng, Xiaozhong, Binnie, Margaret, Wilson, Kris, Hutchinson, Jonathan P, Mirguet, Olivier, Walker, Ann, Beaufils, Benjamin, Ancellin, Nicolas, Trottet,

Journal:

Nature Medicine

Year:

2016

Language:

english

File:

PDF, 1.39 MB

english, 2016

27

What does quality healthcare look like to adolescents and young adults? Ask the experts!

Edwards, M., Lawson, C., Rahman, S., Conley, K., Phillips, H., Uings, R.

Journal:

Clinical Medicine

Year:

2016

Language:

english

File:

PDF, 236 KB

english, 2016

28

Functional analysis of the interleukin-1-receptor-associated kinase (IRAK-1) in interleukin-1β-stimulated nuclear factor κB (NF-κB) pathway activation: IRAK-1 associates with the NF-κB essential modulator (NEMO) upon receptor stimulation

COOKE, Emma-Louise, UINGS, Iain J., XIA, Chulin L., WOO, Patricia, RAY, Keith P.

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 248 KB

english, 2001

29

Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil

Uings, I J, Thompson, N T, Randall, R W, Spacey, G D, Bonser, R W, Hudson, A T, Garland, L G

Journal:

Biochemical Journal

Year:

1992

Language:

english

File:

PDF, 889 KB

english, 1992

30

Functional analysis of the interleukin-1-receptor-associated kinase (IRAK-1) in interleukin-1β-stimulated nuclear factor κB (NF-κB) pathway activation: IRAK-1 associates with the NF-κB essential modulator (NEMO) upon receptor stimulation

COOKE, Emma-Louise, UINGS, Iain J., XIA, Chulin L., WOO, Patricia, RAY, Keith P.

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 248 KB

english, 2001

31

Construction and expression of a functional chimeric receptor from PDGFr-β and c-erbB-2

UINGS, IAIN J., SPACEY, GRAHAM D., BONSER, ROBERT W.

Journal:

Biochemical Society Transactions

Year:

1995

Language:

english

File:

PDF, 176 KB

english, 1995

32

Structure Function Analysis of IRAK-1 in IL-1β and TNFα Signal Transduction to NFκB

Cooke, E., Uings, I., Xia, C., Woo, P., Ray, K.

Journal:

Biochemical Society Transactions

Year:

2000

Language:

english

File:

PDF, 128 KB

english, 2000

33

Cell receptors and cell signalling

Journal:

Molecular Pathology

Year:

2000

Language:

english

File:

PDF, 140 KB

english, 2000

34

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

Hutchinson, Jonathan P., Rowland, Paul, Taylor, Mark R. D., Christodoulou, Erica M., Haslam, Carl, Hobbs, Clare I., Holmes, Duncan S., Homes, Paul, Liddle, John, Mole, Damian J., Uings, Iain, Walker,

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 1.72 MB

english, 2017

35

Binding of monovalent and bivalent ligands by transthyretin causes different short and long distance conformational changes

Corazza, Alessandra, Verona, Guglielmo, Waudby, Christopher Andrew, Mangione, Patrizia P, Bingham, Ryan P, Uings, Iain, Canetti, Diana, Nocerino, Paola, Taylor, Graham W, Pepys, Mark B, Christodoulou,

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 1.22 MB

english, 2019